| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | Naphtho[1,2-d]thiazol-2-ylamine |
| Cas No. | |
| Form | Off-white powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | May be dissolved in DMSO (40mg/ml) |
| Source | Synthetic |
| Storage |
SKA-31 is a pharmacological activator of intermediate-conductance (KCa3.1) and small-conductance (KCa2.x) calcium-activated potassium channels. It has demonstrated blood pressure-lowering effects in hypertensive models by enhancing endothelial function. Although primarily studied in cardiovascular research, SKA-31’s modulation of potassium channels may have implications in neurovascular health and neurodegenerative diseases. Potassium channel activation is associated with improved cerebral blood flow, reduced neuroinflammation, and neuroprotection, making SKA-31 a potential candidate for further exploration in neurological contexts.
Signal word:
Warning
Hazard statement(s):
- H302 Harmful if swallowed.
- H319 Causes serious eye irritation.
Precautionary statement(s):
- P264 Wash skin thoroughly after handling.
- P270 Do not eat, drink or smoke when using this product.
- P280 Wear eye protection/ face protection.
- P301 + P312 + P330 IF SWALLOWED: Call a POISON CENTER/ doctor if you feel unwell. Rinse mouth.
- P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P337 + P313 If eye irritation persists: Get medical advice/ attention.
- P501 Dispose of contents/ container to an approved waste disposal plant.
SKA-31 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-595)
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- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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