| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one |
| Cas No. | |
| Form | Yellow Solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in 75 mM DMSO |
| Source | Synthetic |
| Storage |
SMER3 is a small-molecule modulator that selectively inhibits a yeast SCF (Skp1-Cullin-F-box) family E3 ubiquitin ligase. It induces the expression of MET genes and blocks cell proliferation, and has been identified as an enhancer of rapamycin. Although initially characterized in yeast, SMER3's modulation of ubiquitin ligase activity is of interest in neurodegenerative disease research, where dysregulated protein turnover and autophagy are central to pathogenesis. SMER3 may provide insights into E3 ligase function and its therapeutic modulation in neuronal systems.
Classification: Caution – Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- S24/25- Avoid contact with skin and eyes
SMER3 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-341)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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