| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 5-(3-Trifluoromethylbenzylidene)thiazolidine-2,4-dione |
| Cas No. | |
| Form | Tan solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | May be dissolved in DMSO (100 mg/ml); or Ethanol (40 mg/ml, warm) |
| Source | Synthetic |
| Storage |
SMI-4a is a selective inhibitor of Pim kinases, particularly Pim-1, which are involved in cell survival and proliferation. Although primarily studied in cancer research, SMI-4a is gaining interest in neuroscience for its potential to modulate apoptotic pathways and neuroinflammation. Its ability to influence kinase signaling cascades may offer insights into neuronal survival mechanisms and therapeutic strategies for neurodegenerative diseases.
Hazard statements:
- H317 - May cause an allergic skin reaction
- H319 - Causes serious eye irritation
Precautionary Statements:
- P261 - Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray
- P264 - Wash face, hands and any exposed skin thoroughly after handling
- P272 - Contaminated work clothing should not be allowed out of the workplace
- P280 - Wear protective gloves/ protective clothing/ eye protection/ face protection
- P302 + P352 - IF ON SKIN: Wash with plenty of soap and water
- P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
- do. Continue rinsing
- P333 + P313 - If skin irritation or rash occurs: Get medical advice/ attention
- P337 + P313 - If eye irritation persists: Get medical advice/ attention
- P362 - Take off contaminated clothing and wash before reuse
SMI-4a (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-572)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
