| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Source | Synthetic |
| Molecular formula | C21H13F3N2O. |
| Purity | |
| Activity | |
| Reconstitution | |
| Solubility | Soluble in DMSO. Centrifuge all products before use (10000 x g 5 min). |
| Concentration | |
| Form | Lyophilized powder. |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product details
- Chemical name: 1-phenyl-3-[3-(trifluoromethyl)phenyl]iminoindol-2-one.
- Also known as: HT-2157
- CAS number: 303149-14-6
- Molecular formula: C21H13F3N2O.
- Purity: >98%
- Concentration: 10 nM - 10 µM.
- Form: Lyophilized powder.
- Solubility: Soluble in DMSO. Centrifuge all products before use (10000 x g 5 min).
- Reconstitution: Soluble in DMSO. Centrifuge all products before use (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: Galanin 3 receptor
- Source: Synthetic
- Activity: SNAP 37889 is a potent GalR3 galanin receptor antagonist, highly selective for GalR3 (Ki = 17.44 nM) over GalR1 and GalR2 (Ki > 10 µM), showing anxiolytic and antidepressant-like effects in rodent models in vivo1-2.
- Alternative names: HT-2157
Scientific background
SNAP 37889 is a potent and selective Galanin 3 receptor (GalR3) antagonist. The compound exists as E- and Z-isomers that interconvert quickly in solution at room temperature1,2.Studies conducted in animals show that acute administration of SNAP 37889 enhances rat social interaction, reduces guinea pig vocalizations after maternal separation, and attenuates stress-induced hyperthermia in mice1.Galanin is a widely distributed neuropeptide that regulates various endocrine, pain and cognitive functions, including learning and memory in the central nervous system (CNS). It activates one of three receptors belonging to the GPCR superfamily: GalR1, GalR2 and GalR3. GAL3 receptors are involved in anxiety, depression, and drug-seeking behavior1,2.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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