| Field | Specification |
|---|---|
| Target | |
| Alternative names | NIS, SLC5A5, solute carrier family 5, Na (+)I(-) cotransporter |
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| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | Mannose binding protein and human NIS fusion (AA468-643) |
| Purification | |
| Cellular localization | |
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The Sodium Iodide Symporter (NIS), encoded by the SLC5A5 gene, is a transmembrane glycoprotein responsible for actively transporting iodide ions into thyroid epithelial cells. This iodide uptake is a critical first step in the biosynthesis of thyroid hormones—triiodothyronine (T3) and thyroxine (T4)—which are essential regulators of metabolism, development, and neural function.
While NIS is traditionally studied in the context of thyroid physiology and thyroid cancer imaging, emerging research highlights its broader relevance in neuroscience. Thyroid hormones play a pivotal role in brain development, synaptic plasticity, and neuroprotection. Dysregulation of NIS-mediated iodide transport can impair thyroid hormone synthesis, potentially contributing to cognitive decline, mood disorders, and neurodegenerative diseases such as Alzheimer’s and Parkinson’s.
Recent studies suggest that altered NIS expression or function may influence local thyroid hormone availability in the brain, affecting neuronal energy metabolism and oxidative stress responses. These findings position NIS as a potential biomarker and therapeutic target in neurodegenerative disease research.
Understanding the role of NIS in the neuroendocrine axis opens new avenues for exploring how peripheral thyroid dysfunction may drive central nervous system pathology.
1 µg/ml of SMC-391 was sufficient for detection of hNIS in 20 µg of transfected COS-7 cell membrane lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cite this product varies by variant:
- SMC-391D — Size: 100 ug: Sodium-Iodide Symporter Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-391D, RRID: AB_10804548)
- SMC-391D-A390 — Size: 100 ug: Sodium-Iodide Symporter Antibody: ATTO 390 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-391D-A390, RRID: AB_2700805)
- SMC-391D-A488 — Size: 100 ug: Sodium-Iodide Symporter Antibody: ATTO 488 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-391D-A488, RRID: AB_2700806)
- SMC-391D-A594 — Size: 100 ug: Sodium-Iodide Symporter Antibody: ATTO 594 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-391D-A594, RRID: AB_2700808)
- SMC-391D-APC — Size: 100 ug: Sodium-Iodide Symporter Antibody: APC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-391D-APC, RRID: AB_2700814)
- SMC-391D-BI — Size: 100 ug: Sodium-Iodide Symporter Antibody: Biotin (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-391D-BI, RRID: AB_2700815)
- SMC-391D-FITC — Size: 100 ug: Sodium-Iodide Symporter Antibody: FITC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-391D-FITC, RRID: AB_2700816)
- SMC-391D-HRP — Size: 100 ug: Sodium-Iodide Symporter Antibody: HRP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-391D-HRP, RRID: AB_2700817)
- SMC-391D-PCP — Size: 100 ug: Sodium-Iodide Symporter Antibody: PerCP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-391D-PCP, RRID: AB_2700819)
- SMC-391D-RPE — Size: 100 ug: Sodium-Iodide Symporter Antibody: RPE (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-391D-RPE, RRID: AB_2700820)
- SMC-391S — Size: 12 ug: Sodium-Iodide Symporter Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-391S, RRID: AB_10804548)
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
2. Snabik P.A., et al. (1997) Endocrin. 138(8): 3555-3558.
3. Dohan O., et al. (2007) Proc Natl Acad Sci USA. 104(51): 20250-20255.
