Sodium Valproate

Sodium Valproate is a clinically established anticonvulsant that has garnered significant attention in neuroscience and neurodegenerative disease research due to its multifaceted pharmacological profile. As a histone deacetylase (HDAC) inhibitor (IC50 = 400 µM), it modulates epigenetic regulation, influencing gene expression patterns critical to neuronal survival and plasticity.

Preclinical studies have demonstrated its neuroprotective properties, including the inhibition of amyloid-beta (Aβ) production and reduction of neuritic plaque formation—key pathological features of Alzheimer’s disease. Its anti-inflammatory and anticancer activities further underscore its therapeutic versatility. Sodium Valproate continues to be a focal point in translational neuroscience, offering insights into epigenetic therapies for brain health and disease.

Classification: Caution- Substance not yet fully tested.

Safety Phrases:

• S22 - Do not breathe dust
• S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
• S24/25- Avoid contact with skin and eyes

Sodium Valproate (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-357)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).

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Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).