| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C20H25N5O4S |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
SR121566A is a non-peptide glycoprotein IIb/IIIa (GP IIb-IIIa) antagonist that can inhibit ADP-, arachidonic acid-, and collagen-induced human platelet aggregation, with IC50 values of 46±7.5 nM, 56±6 nM, and 42±3 nM, respectively. Its molecular formula is C20H25N5O4S, with a molecular weight of 431.51 g/mol.
Physical & Chemical Properties
| CAS Number | 180144-61-0 |
|---|---|
| Molecular Formula | C20H25N5O4S |
| Molecular Weight | 431.51 g/mol |
| SMILES | O=C(O)CN1CCC(N(C2=NC(C3=CC=C(C(N)=N)C=C3)=CS2)CCC(O)=O)CC1 |
| Signaling Pathway | Cytoskeleton |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vivo
SR121566A produces dose-dependent increases in TTO, with statistically significant increases at 0.3 mg/kg (473%) and 30 mg/kg (771%), respectively[2].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
Animal Administration[2]
Anesthetize male mice (26-30 g), ventilate them artificially, and place them on a heated jacket to control body temperature. Cannulate a femoral vein for i.v. injections. In thrombosis experiments, give drugs including SR121566A as follows: for intravenous studies, in 0.9% saline (0.1 mL/30 g, 5 min before stimulation); for oral studies, in water (0.1 mL/30 g, 120 min before stimulation)[2].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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