| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C25H25Cl2N7OS |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
SRT 1720 dihydrochloride is a selective, orally active activator of SIRT1, with an EC50 of 0.10 μM, and it shows weaker activity on SIRT2 and SIRT3[1]. It is supplied as a brown to orange solid (C25H25Cl2N7OS, MW 542.48) at 99.60% purity.
Physical & Chemical Properties
| CAS Number | 2468639-77-0 |
|---|---|
| Molecular Formula | C25H25Cl2N7OS |
| Molecular Weight | 542.48 g/mol |
| Purity | 99.60% |
| Appearance | Solid |
| Color | Brown to orange |
| SMILES | O=C(NC1=C(C=CC=C1)C2=CN3C(SC=C3CN4CCNCC4)=N2)C5=NC6=C(N=C5)C=CC=C6.[H]Cl.[H]Cl |
| Target | SIRT1 |
| Signaling Pathway | Cell Cycle/DNA Damage; Epigenetics; Autophagy |
| Solubility | In Vitro: DMSO: 50 mg/mL (92.17 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) H2O: 2.5 mg/mL (4.61 mM; Requires sonication and warming and heat to 60°C) |
| Storage | 4°C, sealed storage, away from moisture. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
Activity & Target
|
SIRT1 0.10 μM (EC50) |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 50 mg/mL (92.17 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
| H2O | 2.5 mg/mL (4.61 mM) | requires sonication and warming and heat to 60°C |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); sealed storage, away from moisture; avoid repeated freeze-thaw cycles.
If water is used as the stock solvent, dilute to the working solution and sterilize it through a 0.22 μm filter before use.
Data provided by the manufacturer.
In Vitro
In cells, SRT 1720 dihydrochloride effectively lowers p53 acetylation even when SIRT1 is absent, an effect attributed to inhibition of the histone acetyltransferase p300[2].
In Vivo
Treatment with SRT 1720 dihydrochloride (10, 30, 100 mg/kg, p.o.) significantly lowers fasting blood glucose to near normal levels in Lepob/ob mice[1]. In mice, SRT 1720 dihydrochloride can protect against the negative effects of diet-induced obesity and is linked to metabolic adaptation in fatty acid and oxidative metabolism through downstream SIRT1 targets such as PGC1α and FOXO1[2]. Given during emphysema development, SRT 1720 dihydrochloride (50-100 mg/kg, p.o.) attenuates elastase-induced airspace enlargement and lung function impairment and also reduces arterial oxygen saturation in WT mice[3].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
Animal Administration[1]
Mice: Feed nine week old C57BL/6 male mice a high fat diet (60% calories from fat) until mean body weight reaches approximately 40 g. Divide the mice into test groups (6-10 per group). Administer SRT1460 (100 mg/kg), SRT 1720 (100 mg/kg), SRT501 (500 mg/kg), and BRL49653 (5 mg/kg) once daily by oral gavage, using 2% HPMC + 0.2% DOSS as the vehicle. Measure individual mouse body weights twice weekly. Take a fed blood glucose measurement at 2, 4, 6, 8 and 10 weeks of dosing, and conduct an IPGTT on all mice from each group after 5 weeks of treatment. After 10 weeks of treatment, conduct an ITT. Complete the statistical analysis with the JMP program, analyzing data by one way ANOVA and comparing against control with Dunnett’s Test. Significant differences between groups are indicated by a p value < 0.05.
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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SARS-CoV-2 virus NSP14 Impairs NRF2/HMOX1 activation by targeting Sirtuin 1. Cell Mol Immunol 2022 Aug;19(8):872-882. PMID: 35732914
Lamin A/C deficiency-mediated ROS elevation contributes to pathogenic phenotypes of dilated cardiomyopathy in iPSC model. Nat Commun 2024 Aug 14;15(1):7000. PMID: 39143095
Metformin attenuates colitis via blocking STAT3 acetylation by reducing acetyl-CoA production. J Adv Res 2025 Mar 31:S2090-1232(25)00218-8. PMID: 40174640
SIRT1 activation synergizes with FXR agonism in hepatoprotection via governing nucleocytoplasmic shuttling and degradation of FXR. Acta Pharm Sin B 2023 Feb;13(2):559-576. PMID: 36873184
HRS Degradation-Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal-Fetal Immune Homeostasis. Adv Sci (Weinh) 2026 Feb;13(11):e10188. PMID: 41532650
NAD+ Metabolism Reprogramming Drives SIRT1-Dependent Deacetylation Inducing PD-L1 Nuclear Localization in Cervical Cancer. Adv Sci (Weinh) 2025 Apr;12(15):e2412109. PMID: 39988985
Hypothyroidism confers tolerance to cerebral malaria. Sci Adv 2022 Apr 8;8(14):eabj7110. PMID: 35385300
S100A8/A9hi neutrophils induce mitochondrial dysfunction and PANoptosis in endothelial cells via mitochondrial complex I deficiency during sepsis. Cell Death Dis 2024 Jun 28;15(6):462. PMID: 38942784
MicroRNA-155-5p promotes neuroinflammation and central sensitization via inhibiting SIRT1 in a nitroglycerin-induced chronic migraine mouse model. J Neuroinflammation 2021 Dec 10;18(1):287. PMID: 34893074
Atractylenolide III from Atractylodes macrocephala Koidz promotes the activation of brown and white adipose tissue through SIRT1/PGC-1α signaling pathway. Phytomedicine 2022 Sep:104:154289. PMID: 35785561
