| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized powder. |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | DMSO or methanol. Centrifuge all product preparations before use (10000 x g 5 min). |
| Source | Natural |
| Storage | |
| Target |
Product details
- Chemical name: [9S-(9a,10b,11b,13a)]-2,3,10,11,12,13-Hexahydro-10- meth oxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo [1,2,3- gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one.
- Also known as: Antibiotic AM-2282
- CAS number: 62996-74-1
- Molecular formula: C28H26N4O3.
- Purity: >98%
- Concentration: 10 nM - 1 µM.
- Form: Lyophilized powder.
- Solubility: DMSO or methanol. Centrifuge all product preparations before use (10000 x g 5 min).
- Reconstitution: DMSO or methanol. Centrifuge all product preparations before use (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: PKA, PKC, PKG
- Source: Natural
- Activity: Staurosporine potently inhibits a variety of kinases including PKC (IC50 = 0.7 nM), PKA (IC50 = 7 nM) and PKG (IC50 = 8.5 nM)1,2. It also inhibits CaMK (IC50 = 20 nM)3 and MLCK (IC50 = 1.3 nM)1,2. In addition, Staurosporine can act as an agonist promoting neurite outgrowth4. At higher concentrations, Staurosporine induces apoptosis5.
- Alternative names: Antibiotic AM-2282
Scientific background
Staurosporine is a member of the K252a family of fungal alkaloids produce by Streptomyces staurospores.1,2 It is one of the most potent, cell permeable protein kinase inhibitors, and it is often used to study the involvement of protein kinases in signal transduction pathways (IC50 0.7-20 nM).3-10In pheochromocytoma PC12 cells, neuroblastoma and brain primary culture Staurosporine is a functional neurotropins agonist promoting neurite outgrowth (EC50 = 50 nM).11-12 At concentrations higher then 0.5 mM, Staurosporine generates apoptosis in several different cell types or induces G1 and G2 phase arrest in normal cells.13-16
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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