| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | N-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolamine |
| Cas No. | |
| Form | Solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in DMSO (26 mg/ml). |
| Source | Synthetic |
| Storage |
STF-62247 is a small molecule known for its selective cytotoxicity in cells deficient in von Hippel-Lindau (VHL) tumor suppressor protein. Although primarily studied in cancer biology, STF-62247 has emerging relevance in neuroscience due to its ability to modulate autophagy and lysosomal function. These pathways are critical in neurodegenerative diseases where impaired clearance of cellular debris contributes to pathology. STF-62247 may serve as a tool to investigate autophagy-dependent cell death and lysosomal stress in neuronal models, offering insights into mechanisms underlying diseases such as Parkinson’s and ALS.
Classification: D1B- Toxic Material Causing Immediate and Serious, Toxic Effects, Toxic by ingestion, D2B- Toxic Material Causing Other Toxic Effects, Moderate eye irritant
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
- H302- Harmful if swallowed.
- H319- Causes serious eye irritation.
Precautionary statements:
P305 + P351 + P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
STF-62247 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-396)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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