| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Source | Plant — Piperaceae Piper boehmeriifolium (Miq.) Wall. ex C. DC.; Plant — Annonaceae Orophea enterocarpa Maingay ex Hook.f. |
| Molecular weight | |
| Molecular formula | C18H15NO5 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Stigmalactam is an aristolactam-type alkaloid extracted from Orophea enterocarpa that has shown anticancer effects. It induces apoptosis through the mitochondrial pathway, activating caspase-3/9 and lowering mitochondrial membrane potential (MTP), and displays antioxidant activity by reducing ROS production; it can be used in liver and breast cancer research[1]. It has the molecular formula C18H15NO5 and a molecular weight of 325.32 g/mol.
Physical & Chemical Properties
| CAS Number | 289499-72-5 |
|---|---|
| Molecular Formula | C18H15NO5 |
| Molecular Weight | 325.32 g/mol |
| Structure Classification | Alkaloids Pyrrole Alkaloids |
| SMILES | O=C1NC2=CC3=CC=C(C=C3C4=C2C1=C(OC)C(OC)=C4OC)O |
| Signaling Pathway | Apoptosis; Metabolic Enzyme/Protease; NF-κB; Immunology/Inflammation |
| Initial Source | Plant — Piperaceae Piper boehmeriifolium (Miq.) Wall. ex C. DC.; Plant — Annonaceae Orophea enterocarpa Maingay ex Hook.f. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
The growth of HepG2, MDA-MB-231, and murine fibroblast NIH3T cells is dose-dependently inhibited by Stigmalactam (24 h), with IC50 values of 22.98 μM, 33.23 μM, and 24.44 μM, respectively[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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