| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C39H46N14O6 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
STING agonist-28 (CF510) is a non-nucleotide small-molecule STING agonist. It has been reported to activate STING, increase phosphorylation of STING, TBK1 and IRF3, raise levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15 and CCL-5 in tumor cells, and show activity against SARS-CoV series strains[1]. It has a molecular formula of C39H46N14O6 and a molecular weight of 806.87 g/mol.
Physical & Chemical Properties
| CAS Number | 2868261-50-9 |
|---|---|
| Molecular Formula | C39H46N14O6 |
| Molecular Weight | 806.87 g/mol |
| SMILES | O=C(C1=CC(C)=NN1CC)NC2=NC3=CC(C(N)=O)=CN=C3N2C/C=C/CN4C5=C(OCCN6CCOCC6)C=C(C(N)=O)C=C5N=C4NC(C7=CC(C)=NN7CC)=O |
| Signaling Pathway | Immunology/Inflammation |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
In THP-1 cells, STING agonist-28 (10 μM; 3 h or 5 h) raises the levels of phosphorylated STING, TBK1 and IRF3 after 3 h of incubation, and raises the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15 after 5 h of incubation, as well as CCL-5[1].
In Vivo
As an adjuvant, STING agonist-28 (im; 3 times at 14-day intervals; 20 μg STING agonist-28 together with 5 μg RBD-Fc per mouse) elicits a strong antibody immune response to the SARS-CoV-2 RBD-Fc protein in a mouse model[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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