| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C21H14N2O5 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
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Compound Overview
STO-609 acetate is a selective, cell-permeable inhibitor of Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK), with Ki values of 80 ng/mL for recombinant CaM-KKα and 15 ng/mL for CaM-KKβ. It also inhibits AMP-activated protein kinase kinase (AMPKK) activity in HeLa cell lysates, with an IC50 of approximately 0.02 g/mL. It has a molecular formula of C21H14N2O5 and a molecular weight of 374.35 g/mol.
Physical & Chemical Properties
| CAS Number | 1173022-21-3 |
|---|---|
| Molecular Formula | C21H14N2O5 |
| Molecular Weight | 374.35 g/mol |
| SMILES | O=C(C1=C2C3=C(C4=NC5=CC=CC=C5N4C(C3=CC=C2)=O)C=C1)O.CC(O)=O |
| Signaling Pathway | Neuronal Signaling; Autophagy; PI3K/Akt/mTOR; Epigenetics |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Recombinant CaM-KKα and CaM-KKβ isoforms are inhibited by STO-609 with Ki values of 80 and 15 ng/mL, respectively, and their autophosphorylation activities are inhibited as well. STO-609 is highly selective for CaM-KK, with no significant effect on the downstream CaM kinases (CaM-KI and -IV); its IC50 against CaM-KII is 10 μg/mL. STO-609 inhibits both constitutively active CaM-KKα and the wild-type enzyme. In transfected HeLa cells, STO-609 suppresses Ca2+-induced activation of CaM-KIV in a dose-dependent manner. At 1μg/mL, STO-609 significantly lowers endogenous CaM-KK activity in SH-SY5Y neuroblastoma cells (80% inhibitory rate)[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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