| Field | Specification |
|---|---|
| Alternative names | Agrept; Agrimycin; Streptomycin A |
| CAS no. | |
| Applications | |
| Source | Microbial — Streptococcus |
| Molecular weight | |
| Molecular formula | C21H39N7O12 |
| Purity | |
| Activity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Streptomycin, also known as Agrept, Agrimycin, or Streptomycin A, is an effective antibiotic against M. tuberculosis and can be used for tuberculosis (TB) research. It is also a bactericidal agent that can be used to study a number of bacterial infections. It can bind strongly to nucleic acids and interferes with and blocks protein synthesis while permitting continued RNA and DNA synthesis. As a common antibiotic used in culture media, it also blocks stretch-activated and mechanosensitive ion channels in neurons and cardiac myocytes[1][2][3]. It is supplied as a white to off-white solid (C21H39N7O12, MW 581.57) at 99.91% purity.
Physical & Chemical Properties
| CAS Number | 57-92-1 |
|---|---|
| Molecular Formula | C21H39N7O12 |
| Molecular Weight | 581.57 g/mol |
| Purity | 99.91% |
| Appearance | Solid |
| Color | White to off-white |
| Structure Classification | Others |
| SMILES | N=C(N)N[C@@H]([C@@H]([C@H]([C@@H]([C@H]1O)O)NC(N)=N)O)[C@H]1O[C@H](O[C@H]([C@]2(O)C=O)C)[C@@H]2O[C@H]3[C@H]([C@@H]([C@H]([C@@H](O3)CO)O)O)NC |
| Signaling Pathway | Anti-infection |
| Bioactivity Class | Aminoglycoside |
| Initial Source | Microbial — Streptococcus |
| Solubility | In Vitro: H2O: 125 mg/mL (214.94 mM; Requires sonication) |
| Storage | Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| H2O | 125 mg/mL (214.94 mM) | requires sonication |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); avoid repeated freeze-thaw cycles.
If water is used as the stock solvent, dilute to the working solution and sterilize it through a 0.22 μm filter before use.
Data provided by the manufacturer.
In Vitro
Streptomycin acts as a potent inhibitor of hypotonicity-induced Ca2+ entry and of Cl channel activity[3].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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