| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one |
| Cas No. | |
| Form | Orange solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in DMSO (25 mg/ml) |
| Source | Synthetic |
| Storage |
SU 4312 is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases, including VEGFR-2 (Flk-1/KDR). In neurodegenerative disease research, SU 4312 is used to investigate the role of VEGF and PDGF signaling in neurovascular remodeling, glial activation, and neuronal survival. Its ability to modulate angiogenic and inflammatory pathways makes it a valuable tool for studying the vascular component of neurodegeneration and brain repair mechanisms.
Classification: Skin irritation (Category 2), H315
Eye irritation (Category 2A), H319
Specific target organ toxicity -single exposure (Category 3), Respiratory system, H335
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
- H315 Causes skin irritation.
- H319 Causes serious eye irritation.
- H335 May cause respiratory irritation.
Precautionary statements:
- P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
- P264 Wash skin thoroughly after handling.
- P271 Use only outdoors or in a well-ventilated area.
- P280 Wear protective gloves/ eye protection/ face protection.
- P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
- P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
- P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P312 Call a POISON CENTER or doctor/ physician if you feel unwell.
- P321 Specific treatment (see supplemental first aid instructions on this label).
- P332 + P313 If skin irritation occurs: Get medical advice/ attention.
- P337 + P313 If eye irritation persists: Get medical advice/ attention.
- P362 Take off contaminated clothing and wash before reuse.
- P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
- P405 Store locked up.
- P501 Dispose of contents/ container to an approved waste disposal plant.
SU 4312 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-481)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. Shimotake J., Derugin N., Wendland M., Vexler Z.S., & Ferriero D.M. (2010) Stroke. 41(2): 343–349.
3. Schultheiss C., et al. (2006) Angiogenesis. 9(2): 59–65.
