| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | {(1Z)-5-Fluoro-2-methyl-1-[4-(methylsulfanyl)benzylidene]-1H-inden-3-yl}acetic acid |
| Cas No. | |
| Form | Yellow solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble to 25 mM in DMSO, 3 mM in ethanol |
| Source | Synthetic |
| Storage |
Sulindac sulfide is the active metabolite of the nonsteroidal anti-inflammatory drug (NSAID) sulindac. It exerts its effects by inhibiting cyclooxygenase (COX) enzymes, thereby reducing prostaglandin synthesis and inflammation. In neuroscience, sulindac sulfide has been investigated for its ability to induce apoptosis in abnormal cells and modulate neuroinflammatory pathways. Its potential to reduce oxidative stress and inflammation makes it a candidate for neuroprotective strategies in neurodegenerative diseases.
Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
- R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed
- R62 - Possible risk of impaired fertility
Hazard Phrases:
H302-H317-H334-H361
Precautionary Phrases:
P261-P280-P342 + P311
Sulindac Sulfide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-261)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. Piazza G.A., et al. (1997) Cancer Res. 57(12): 2452-2459.
