| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | {(1Z)-5-Fluoro-2-methyl-1-[4-(methylsulfonyl)benzylidene]-1H-inden-3-yl}acetic acid |
| Cas No. | |
| Form | Yellow solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble to 25 mM in DMSO, 3 mM in ethanol |
| Source | Synthetic |
| Storage |
Sulindac sulfone is a non-COX-inhibiting metabolite of sulindac that retains anti-inflammatory and pro-apoptotic properties. Unlike sulindac sulfide, it does not inhibit prostaglandin synthesis but selectively induces apoptosis in abnormal cells. In neurodegenerative disease research, sulindac sulfone is being explored for its ability to modulate cell survival pathways and reduce neuroinflammation, offering a complementary mechanism of action to traditional NSAIDs.
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Sulindac Sulfone (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-262)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. Piazza G.A., et al. (1997) Cancer Res. 57(12): 2452-2459.
