| Field | Specification |
|---|---|
| Alternative names | NHS-Glutarate-Val-Cit-PAB-MMAE |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C67H103N11O17 |
| Purity | |
| Activity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
SuO-Glu-Val-Cit-PAB-MMAE, also known as NHS-Glutarate-Val-Cit-PAB-MMAE, consists of a cleavable ADC linker (SuO-Glu-Val-Cit-PAB) and a potent tubulin inhibitor (MMAE). It can be used in the synthesis of antibody-drug conjugates (ADCs)[1]. It is supplied as a white to off-white solid (C67H103N11O17, MW 1334.60) at 99.38% purity.
Physical & Chemical Properties
| CAS Number | 1895916-24-1 |
|---|---|
| Molecular Formula | C67H103N11O17 |
| Molecular Weight | 1334.60 g/mol |
| Purity | 99.38% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | CC[C@H](C)[C@@H]([C@@H](CC(N1[C@@H](CCC1)[C@@H]([C@@H](C)C(N[C@H](C)[C@@H](O)C2=CC=CC=C2)=O)OC)=O)OC)N(C([C@H](C(C)C)NC([C@H](C(C)C)N(C(OCC3=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCC(ON4C(CCC4=O)=O)=O)=O)=O)=O)C=C3)=O)C)=O)=O)C |
| Signaling Pathway | Antibody-Drug Conjugate/ADC Related |
| Bioactivity Class | Auristatin |
| Solubility | In Vitro: DMSO: 100 mg/mL (74.93 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | -80°C, protect from light. The compound is unstable in solutions, freshly prepared is recommended. |
| Shipping | Shipping with dry ice. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 100 mg/mL (74.93 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
The manufacturer notes that the compound is unstable in solution; prepare solutions fresh before use.
Data provided by the manufacturer.
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