| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C20H31NO6 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Symphytine is a pyrrolizidine alkaloid isolated from Symphytum officinale that has been reported to exhibit carcinogenicity[1]. It has the molecular formula C20H31NO6 and a molecular weight of 381.46 g/mol.
Physical & Chemical Properties
| CAS Number | 22571-95-5 |
|---|---|
| Molecular Formula | C20H31NO6 |
| Molecular Weight | 381.46 g/mol |
| SMILES | C/C=C(C)/C(O[C@H]1[C@@]2([H])C(COC([C@@](C(C)C)(O)[C@@H](O)C)=O)=CCN2CC1)=O |
| Signaling Pathway | Cancer |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vivo
Symphytine (intraperitoneal injection; 13 mg/kg; 330 days) allows survival beyond 330 days from the first injection. Four of 20 rats (20%) developed liver tumors: three had hemangioendothelial sarcoma and 1 had liver cell adenoma[1].
| Animal Model | Male inbred ACI rats[1] |
|---|---|
| Dosage | 13 mg/kg |
| Administration | Intraperitoneal injection; 330 days |
| Result | Led to hepatic tumor in rats. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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