| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C15H16ClI2NO3 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
T2AA hydrochloride is the non-peptide small-molecule PCNA inhibitor T2 amino alcohol (T2AA), which lacks thyroid hormone activity. It inhibits the interaction of PCNA with the PIP-box peptide (IC50 of approximately 1 μM) and the interaction of PCNA with full-length p21 protein[1].
It has the molecular formula C15H16ClI2NO3 and a molecular weight of 547.55 g/mol.
Physical & Chemical Properties
| CAS Number | 2138331-07-2 |
|---|---|
| Molecular Formula | C15H16ClI2NO3 |
| Molecular Weight | 547.55 g/mol |
| SMILES | IC(C=C(C=C1I)C[C@H](N)CO)=C1OC2=CC=C(C=C2)O.Cl |
| Signaling Pathway | Cell Cycle/DNA Damage |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).
A genetic screen for modifiers of cohesin clustering identifies regulators of genome folding. Sci Adv 2026 Jan 30;12(5):eadx5130. PMID: 41616049
IodoFinder: Machine Learning-Guided Recognition of Iodinated Chemicals in Nontargeted LC-MS/MS Analysis. Environ Sci Technol 2025 Mar 11;59(9):4530-4539. PMID: 40015982
