| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 2-(3,5-Dichlorophenyl)-1,3-Benzoxazole-6-Carboxylic Acid, FX-1006, 2-(3,5-Dichlorophenyl)-6-benzoxazole carboxylic acid |
| Cas No. | |
| Form | Off-white powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | May be dissolved in DMSO (25 mg/ml, warm) |
| Source | Synthetic |
| Storage |
Tafamidis is a pharmacological chaperone that stabilizes the tetrameric form of transthyretin (TTR), preventing its dissociation into monomers that can misfold and aggregate. While its primary clinical application is in delaying peripheral nerve damage in familial amyloid polyneuropathy (FAP), Tafamidis is increasingly recognized for its relevance in systemic amyloidosis research.
Although not widely studied in neurodegenerative disease models, its mechanism—preventing amyloid fibril formation—parallels pathological processes in Alzheimer’s and other protein misfolding disorders. Tafamidis serves as a model compound for exploring amyloid stabilization strategies and may inform future therapeutic approaches targeting neurodegenerative amyloidoses.
Classification: Danger- Irritant and Health Hazards GHS Hazard Statements: H315: Causes skin irritation
H319:
Causes serious eye irritation
H335:
May cause respiratory irritation
H360:
May damage fertility or the unborn child Precautionary Statements: P201, P202, P261, P264, P271, P280, P281, P302+P352, P304+P340, P305+P351+P338, P308+P313, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501
Tafamidis (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-584)
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