| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized Powder |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | 100 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: 6-prop-2-enyl-4,5,7,8-tetrahydro-[1,3]thiazolo[4,5-d]azepin-2-amine;dihydrochloride.
- Also known as: B-HT 920
- CAS number: 36085-73-1
- Molecular formula: C10H15N3S•2HCl.
- Purity: >98%
- Concentration: 0.3-300 nM.
- Form: Lyophilized Powder
- Solubility: 100 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
- Reconstitution: Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. Repeat freeze-thawing may result in loss of activity
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: 5-HT3, D2 dopamine, α2-adrenoceptor receptors
- Source: Synthetic
- Activity: B-HT 920 is a blocker of 5-HT3 channels1. It is also an agonist of D2 dopamine receptors and α2-adrenoceptors.
- Alternative names: B-HT 920
Scientific background
Talipexole is an azepine derivative, and acts as an agonist of D2 dopamine pre- and postsynaptic receptors, as well as an α2-adrenoceptor agonist and 5-HT3 receptor antagonist1.The purpose of Talipexole is to increase dopamine activity in the central nervous system. It inhibits electrically evoked release of dopamine through activation of D2 synaptic autoreceptors located on dopaminergic terminals. It also causes release of acetylcholine and noradrenalin2,3.Talipexole has been established in a number of clinical trials as an anti-Parkinsonian agent. These trials showed significant improvement in motor activity and in other parkinsonian symptoms including akinesia, rigidity, tremor and gait disturbances. There are several side effects caused by this drug such as drowsiness, dizziness, hallucinations, gastrointestinal discomfort, nausea and loss of appetite3.In addition, talipexole is also expected to be beneficial for the treatment of periodic leg movement disorder and restless leg syndrome4.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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