| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C41H67N7O6S |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
TAM470 is a novel cytolysin that inhibits tubulin polymerization and microtubule depolymerization. It can be used as a payload molecule in the synthesis of OMTX705, a FAP-targeting antibody-drug conjugate (ADC) with antitumor activity[1]. It is supplied as a white to off-white solid (C41H67N7O6S, MW 786.08) at 95.64% purity.
Physical & Chemical Properties
| CAS Number | 1802498-63-0 |
|---|---|
| Molecular Formula | C41H67N7O6S |
| Molecular Weight | 786.08 g/mol |
| Purity | 95.64% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | O=C([C@@H]1N(CCCC1)C)N[C@@H]([C@@H](C)CC)C(N(CCC)[C@@H](C(C)C)C[C@H](C2=NC(C(N[C@H](C[C@H](C)C(NN)=O)CC3=CC=C(C=C3)O)=O)=CS2)OCCC)=O |
| Signaling Pathway | Cell Cycle/DNA Damage; Cytoskeleton; Antibody-Drug Conjugate/ADC Related |
| Solubility | In Vitro: DMSO: 100 mg/mL (127.21 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | 4°C, stored under nitrogen. In solvent: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 100 mg/mL (127.21 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); stored under nitrogen; avoid repeated freeze-thaw cycles.
In Vivo
Choose the formulation that suits the animal model and route of administration; percentages are volume ratios of the final working solution. Start from a clear DMSO stock (see In Vitro above), add the co-solvents one at a time in the order listed, mixing after each addition, and prepare the working solution fresh on the day of dosing. If precipitation or phase separation occurs, gentle warming or sonication can help.
Protocol 1
| Composition | 10% DMSO + 40% PEG300 + 5% Tween-80 + 45% saline |
|---|---|
| Result | ≥ 2 mg/mL (2.54 mM); clear solution |
| How to prepare | Gives a clear solution at ≥ 2 mg/mL (saturation not determined). For 1 mL of working solution: add 100 μL DMSO stock (20.0 mg/mL) to 400 μL PEG300; then 50 μL Tween-80; then 450 μL saline to bring the volume to 1 mL. Saline: dissolve 0.9 g sodium chloride in ddH2O and make up to 100 mL. |
Protocol 2
| Composition | 10% DMSO + 90% Corn Oil |
|---|---|
| Result | ≥ 2 mg/mL (2.54 mM); clear solution |
| How to prepare | Gives a clear solution at ≥ 2 mg/mL (saturation not determined). Use with caution if continuous dosing will exceed two weeks. For 1 mL of working solution: add 100 μL DMSO stock (20.0 mg/mL) to 900 μL corn oil. |
Data provided by the manufacturer.
In Vitro
TAM470 binds to β-tubulin, destroys α-β tubulin heterodimers, and inhibits microtubule polymerization and depolymerization[1]. Cytotoxicity is exhibited by TAM470 (10 nM-100 μM, 5 days) in wildtype HT1080, FAP-expressing HT1080, and CAF07[1].
Cell Viability Assay[1]
| Cell Line | HT1080 WT, HT1080-FAP, CAF |
|---|---|
| Concentration | 10 nM-100 μM |
| Incubation Time | 5 days |
| Result | Reduced the cell density. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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