| Field | Specification |
|---|---|
| Target | |
| Alternative names | ICI 46474; (Z)-Tamoxifen Citrate; trans-Tamoxifen Citrate |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C32H37NO8 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Tamoxifen Citrate, also known as ICI 46474, (Z)-Tamoxifen Citrate, or trans-Tamoxifen Citrate, is an orally active, selective estrogen receptor modulator (SERM) that blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. It is a potent activator of Hsp90, enhancing the Hsp90 molecular chaperone ATPase activity, and potently inhibits infectious EBOV Zaire and Marburg (MARV), with IC50 values of 0.1 μM and 1.8 μM, respectively. It activates autophagy and induces apoptosis, and can be used to induce gene knockout in CreER transgenic mice[1][2][3][4][5][6]. It is supplied as a white to off-white solid (C32H37NO8, MW 563.64) at 99.88% purity.
Physical & Chemical Properties
| CAS Number | 54965-24-1 |
|---|---|
| Molecular Formula | C32H37NO8 |
| Molecular Weight | 563.64 g/mol |
| Purity | 99.88% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | CC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCN(C)C)C=C2)\C3=CC=CC=C3.O=C(CC(C(O)=O)(O)CC(O)=O)O |
| Target | Estrogen receptor, HSP90 |
| Signaling Pathway | Vitamin D Related/Nuclear Receptor; Metabolic Enzyme/Protease; Cell Cycle/DNA Damage; Autophagy; Apoptosis |
| Solubility | In Vitro: DMSO: 50 mg/mL (88.71 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Ethanol: 10 mg/mL (17.74 mM; Requires sonication) H2O: < 0.1 mg/mL (insoluble) |
| Storage | 4°C, sealed storage, away from moisture. In solvent: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[1]. Osborne CK. Tamoxifen in the treatment of breast cancer. N Engl J Med. 1998 Nov 26;339(22):1609-18.
[6]. Feil S, et al. Inducible Cre mice. Methods Mol Biol. 2009;530:343-63.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 50 mg/mL (88.71 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
| Ethanol | 10 mg/mL (17.74 mM) | requires sonication |
| H2O | < 0.1 mg/mL | insoluble |
Aliquot the stock solution and store it at -80°C (up to 1 year) or -20°C (up to 6 months); sealed storage, away from moisture; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
Tamoxifen Citrate (ICI 46474) strongly inhibits MCF-7 cells (EC50=1.41 μM) and, to a lesser extent, T47D cells (EC50=2.5 μM), but has no effect on MDA-MB-231 cells[2].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
Animal Administration[3]
Mice[3] Administer Tamoxifen intraperitoneally to seven-week old TmcsMed1-/- mice and wild-type littermates at a daily dose of 65 mg/kg body weight for 5 days, then kill the animals at selected intervals after initiation of Tamoxifen treatment. Use 3 to 5 mice per group (control and csMed1-/-) for each experiment. For the survival curve, use 41 csMed1-/- and 41 csMed1fl/fl mice. For the survival curve experiments with the Tamoxifen inducible model, use thirteen TmcsMed-/- mice and the same number of littermates.
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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