| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized powder. |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | 10 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: sodium;1,6,6-trimethyl-10,11-dioxo-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-2-sulfonate.
- Also known as: DS-201
- CAS number: 69659-80-9
- Molecular formula: C19H17O6SNa.
- Purity: ≥98%
- Concentration: 10-200 µM.
- Form: Lyophilized powder.
- Solubility: 10 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
- Reconstitution: 10 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: KCa1.1 channel
- Source: Synthetic
- Activity: Tanshinone II-A sodium sulfonate is a KCa1.1 channel opener1.
- Alternative names: DS-201
Scientific background
KCa1.1 channel is a large conductance Calcium-activated potassium channel (BKCa) known to regulate the repolarization of action potential discharge through molecular association with high voltage activated calcium channels.Tanshinone II-A sodium sulfonate (TIIAS) is a water soluble derivative of Tanshinone IIA. Tanshinone IIA is an active constituent of the herb Danshen (Salvia miltiorrhiza) widely used in Chinese traditional medicine for coronary artery disease, hypertension and other cardiovascular diseases due to its properties of arterial dilatation. TIIAS is a synthetic opener of KCa1.1 channels with an effective concentration 10-200 μM. TIIAS increases the total permeability of BKCa in a concentration dependent manner. TIIAS has an EC50 of 111.5 μM at 0.01 μM Ca2+ and an EC50 of 68.5 μM at 0.1 μM Ca2+ 2. Similar to Danshen, TIIAS has beneficial effects on cardiac vasodilatation, reduction of oxidative stress and lipid profile. Interestingly, when used in a rat model of preeclampsia TIIAS reduced oxidative stress, however it did not lead to an improvement in pregnancy outcome criteria such as maternal blood pressure and fetal biometrics3. TIIAS was also found to have analgesic properties in neuropathic pain via inhibition of the spinal astrocytic JNK/MCP-1 pathway and the reduction of IL-1β and TNF-α expression4.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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