TCID

TCID is a cell-permeable inhibitor of ubiquitin C-terminal hydrolase L3 (UCHL3), with an IC50 of 0.6 µM and high selectivity over UCHL1. UCHL3 is involved in the processing of ubiquitin precursors and the recycling of ubiquitin from substrates, playing a critical role in maintaining ubiquitin homeostasis. In the context of neurodegeneration, dysregulation of deubiquitinating enzymes like UCHL3 may contribute to protein aggregation and neuronal dysfunction. TCID serves as a chemical probe to dissect the role of UCHL3 in neuronal systems and may support the development of targeted therapies for diseases involving ubiquitin pathway dysregulation.

Classification: Caution – Substance not yet fully tested.

Safety Phrases:

• S22 - Do not breathe dust
• S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
• S24/25- Avoid contact with skin and eyes

Precautionary Statements:

• P260- Do not breathe dust/fume/gas/mist/vapours/spray.
• P285- In case of inadequate ventilation wear respiratory protection.
• P305+P351+P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P310- Immediately call a POISON CENTER or doctor/physician.
• P501- Dispose of contents/container in accordance with international regulations.

Hazard Statements:

• H334- May cause allergy or asthma symptoms or breathing difficulties if inhaled
• H373- May cause damage to organs through prolonged or repeated exposure
• H318- Causes serious eye damage
• H410- Very toxic to aquatic life with long lasting effects
• H317- May cause an allergic skin reaction

TCID (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-340)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).

Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).