TCN 213

Product details

• Chemical name: 2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(cyclohexylmethyl)acetamide.
• Also known as: AC1M9FKI
• CAS number: 556803-08-8
• Molecular formula: C18H24N4OS2.
• Purity: >99%
• Concentration: 1 µM - 1 mM.
• Form: Lyophilized powder.
• Solubility: Up to 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
• Reconstitution: Up to 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
• Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
• Target: NMDA receptors
• Source: Synthetic
• Activity: TCN 213 is a NMDA receptor antagonist, selective for NR2A- over NR2B-containing receptors. Inhibits human recombinant NR1/NR2A with pIC50 of 5.4 in FLIPR/Ca2+ assay1.
• Alternative names: AC1M9FKI

Scientific background

TCN 213 acts as a selective and potent NMDA (methyl-d-aspartate) receptor antagonist. This compound displays a high selectivity for GluN1/GluN2A-containing NMDAR receptors over GluN1GluN1/GluN2B containing NMDAR receptors. The degree of its antagonism is dependent on the concentration of the GluN1-site co-agonist, glycine or d-serine, and is independent of the glutamate concentration1. Relatively high concentrations of TCN 213 are required to achieve substantial block of GluN2A NMDAR-mediated responses.NMDA receptors are heterotetrameric channels formed by the assembly of two obligatory GluN1 and two GluN2/GluN3 subunits. NMDAR plays an important role in a variety of cellular processes and brain functions such as, synaptic plasticity, addiction and stroke. NMDA receptors mediate physiological functions such as learning and memory formation. They play a role in glutamate excitotoxicity and are involved in many neurodegenerative conditions including Alzheimer's disease2.

Lead time: 1-2 Business Days

Country of origin: Israel/IL

Applications key

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Bioassay tested: Yes

• SDS (PDF)

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