| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C27H38O4 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
TEI-9648, a vitamin D3 lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. It inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)2D3 and also inhibits HL-60 cell differentiation induced by 1α,25(OH)2D3, and it has potential relevance to bone metabolism research[1][2]. It is supplied as an off-white to yellow solid (C27H38O4, MW 426.59) at 99.24% purity.
Physical & Chemical Properties
| CAS Number | 173388-21-1 |
|---|---|
| Molecular Formula | C27H38O4 |
| Molecular Weight | 426.59 g/mol |
| Purity | 99.24% |
| Appearance | Solid |
| Color | Off-white to yellow |
| SMILES | O=C1O[C@H](C[C@H]([C@H]2CC[C@@]3([H])/C(CCC[C@]23C)=C/C=C4C([C@@H](O)C[C@H](O)C\4)=C)C)CC1=C |
| Signaling Pathway | Vitamin D Related/Nuclear Receptor |
| Solubility | In Vitro: DMSO: 50 mg/mL (117.21 mM; Requires sonication and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | 4°C, protect from light, stored under nitrogen. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 50 mg/mL (117.21 mM) | requires sonication and warming and heat to 60°C; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); protect from light, stored under nitrogen; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
TEI-9648 (10-1000 nM) blocks, in a dose-dependent manner, the reciprocal changes of CD11b and CD71 expression that accompany HL-60 cell differentiation induced by 1α,25(OH)2D3[1]. TEI-9648 shows a consistently weaker suppressive effect than TEI-9647[1]. TEI-9648 cannot induce cell differentiation in HL-60 cells, even after treatment at 1 μM[1]. TEI-9648 alone cannot activate NBT-reducing activity or α-NB esterase activity. By contrast, in HL-60 cells, TEI-9648 markedly suppresses the up-regulation that 1α,25(OH)2D3 (0.1 nM) induces[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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Antiviral activity of vitamin D derivatives against severe fever with thrombocytopenia syndrome virus in vitro and in vivo. Virol Sin 2024 Oct;39(5):802-811. PMID: 39168248
