| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | Geranylgeranylacetone, GGA, 6,10,14,18-Tetramethyl-5,9,13,17-nonadecatetraen-2-one |
| Cas No. | |
| Form | Colorless Oil |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in DMSO (30 mg/ml) |
| Source | Synthetic |
| Storage |
Teprenone is a cytoprotective agent known for its ability to induce heat shock proteins (HSPs), notably HSP70, HSPB8, and HSPB1. In neurodegenerative disease research, Teprenone has shown promise by reducing the formation of amyloid oligomers and insoluble aggregates, which are key pathological features in disorders such as Alzheimer's and spinal and bulbar muscular atrophy. Its neuroprotective effects are attributed to the upregulation of HSPs, which help maintain protein homeostasis and reduce cellular stress. Teprenone’s ability to cross the blood-brain barrier and modulate stress response pathways positions it as a potential therapeutic candidate in neurodegeneration and neuroinflammation.
Classification: Not a hazardous substance or mixture.
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Teprenone (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-526)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. Sambroski P., Grzymislawski M. (2015) Adv Clin Med. 24(3): 525-530.
3. Marunouchi T., Inomata S., Sanbe A., Takagi N., Tanonaka K. (2014) Eur J Pharmacol. 730: 1401-47.
4. Sanbe A., et al. (2009) PLoS One. 4(4): e5351.
