| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C6H14NNaO6S |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
TES sodium is an effective hydrogen ion buffer with an appropriate dissociation constant, a low metal-binding constant, and high water solubility. It can be used in research involving mammalian cell culture and viruses, among other applications[1][2]. It is supplied as a white to off-white solid (C6H14NNaO6S, MW 251.23) at 98.0% purity.
Physical & Chemical Properties
| CAS Number | 70331-82-7 |
|---|---|
| Molecular Formula | C6H14NNaO6S |
| Molecular Weight | 251.23 g/mol |
| Purity | 98.0% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | OCC(NCCS(=O)(O[Na])=O)(CO)CO |
| Solubility | In Vitro: H2O: 250 mg/mL (995.10 mM; Requires sonication) DMSO: 83.33 mg/mL (331.69 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | 4°C, sealed storage, away from moisture. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[1]. N E Good, et al. Hydrogen ion buffers for biological research. Biochemistry. 1966 Feb;5(2):467-77.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| H2O | 250 mg/mL (995.10 mM) | requires sonication |
| DMSO | 83.33 mg/mL (331.69 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); sealed storage, away from moisture; avoid repeated freeze-thaw cycles.
If water is used as the stock solvent, dilute to the working solution and sterilize it through a 0.22 μm filter before use.
Data provided by the manufacturer.
In Vitro
The pKa values of TES (0.1 M) sodium are 7.92 at 0°, 7.50 at 20°, and 7.14 at 37°, and a saturated aqueous solution of it reaches 2.6 M at 0°[1]. In a closed culture environment, TES (6-50 mM; 11-14 days) sodium is similar to, or even more effective than, NaHCO3-CO2-buffered medium regarding the efficiency of colony formation, the size of colonies, and cell morphology across several mammalian cell lines (HeLa S3, KB, BHK 21-Cl3, 3Y1-B Cl-1)[2]. In the SV40 virus plaque assay with monkey kidney CV-1 cells, TES (25-50 mM; 14-19 days) sodium shows efficiency similar to NaHCO3-CO2-buffered medium, with a shorter required time[2].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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