| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | Centrifuge the vial before adding solvent (10,000 x g for 5 minutes). The lyophilizate may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. TX citrate is freely soluble in water to over 10 mM The reconstituted product contains citrate buffer.To reconstitute 1 mg lyophilized product to 10 mM stock solution - add 313 µl ddH2O to the vial and tap gently until fully dissolved. To reconstitute 50 µg lyophilized product to 1 mM stock solution - add 157 µl ddH2O to the vial and tap gently until fully dissolved.Centrifuge all product vials before handling and reconstitution (10000 x g 5 min). |
| Source | Natural |
| Storage | |
| Target |
Product details
- Chemical name: Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethan o-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol.
- Also known as: TTX
- CAS number: 18660-81-6
- Molecular formula: C11H17N3O8
- Purity: >99% (HPLC)
- Concentration: 100 nM - 1 μM
- Form: Lyophilized
- Solubility: Centrifuge the vial before adding solvent (10,000 x g for 5 minutes). The lyophilizate may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. TX citrate is freely soluble in water to over 10 mM The reconstituted product contains citrate buffer.To reconstitute 1 mg lyophilized product to 10 mM stock solution - add 313 µl ddH2O to the vial and tap gently until fully dissolved. To reconstitute 50 µg lyophilized product to 1 mM stock solution - add 157 µl ddH2O to the vial and tap gently until fully dissolved.Centrifuge all product vials before handling and reconstitution (10000 x g 5 min).
- Reconstitution: Centrifuge the vial before adding solvent (10,000 x g for 5 minutes). The lyophilizate may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. TX citrate is freely soluble in water to over 10 mM The reconstituted product contains citrate buffer.To reconstitute 1 mg lyophilized product to 10 mM stock solution - add 313 µl ddH2O to the vial and tap gently until fully dissolved. To reconstitute 50 µg lyophilized product to 1 mM stock solution - add 157 µl ddH2O to the vial and tap gently until fully dissolved.Centrifuge all product vials before handling and reconstitution (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: Various NaV channels
- Source: Natural
- Activity: Tetrodotoxin is a potent and selective blocker of a subclass of NaV channels1, and is often used to define subclasses of NaV channels2.
- Applications: Electrophysiology
- Alternative names: TTX
Specificity
A Classic Blocker of a Subset of NaV Channels
Scientific background
Tetrodotoxin (TTX) is an established potent and selective blocker of some NaV channels.1 Moreover, TTX sensitivity is used to define subclasses of NaV channels.2 It is widely used both to probe NaV activity and to reduce or block excitability in neurophysiological preparations.
Applications may also work in
Electrophysiology
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
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