Tetrodotoxin citrate free
Tetrodotoxin citrate free (CAS 4368-28-9) is Tetrodotoxin is a potent and selective blocker of a subclass of NaV channels1, and is often used to define subclasses of NaV channels2. Supplied as Lyophilized Powder (purity >99% (HPLC), solubility Acidic buffer (pH 4.8). Centrifuge all product preparations before use (10000...). Commonly used in Neuroscience studies, including patch-clamp electrophysiology and ion channel screening.
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Overview
What is Tetrodotoxin citrate free?
Product details
- Chemical name: Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10adimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol.
- Also known as: TTX
- CAS number: 4368-28-9
- Molecular formula: C11H17N3O8.
- Purity: >99% (HPLC)
- Concentration: 100 nM - 1 µM.
- Form: Lyophilized Powder
- Solubility: Acidic buffer (pH 4.8). Centrifuge all product preparations before use (10000 x g 5 min).
- Reconstitution: Acidic buffer (pH 4.8). Centrifuge all product preparations before use (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: Various NaV Na+ channels
- Source: Natural
- Activity: Tetrodotoxin is a potent and selective blocker of a subclass of NaV channels1, and is often used to define subclasses of NaV channels2.
- Alternative names: TTX
Scientific background
Tetrodotoxin (TTX) is an established potent and selective blocker of some NaV channels.1 Moreover, TTX sensitivity is used to define subclasses of NaV channels.2 It is widely used both to probe NaV activity and to reduce or block excitability in neurophysiological preparations.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
Details
Specifications
Applications
Applications & how to use
Functional Assay (In Vitro)
A cell-free biochemical readout performed in a tube or microplate, where purified components are reconstituted so a single molecular event can be measured in isolation. Preferred when the goal is a direct, interpretable measurement without the confounding variables of a cellular system.
Evidence
Validation & QC
Validation data for this product isn’t published yet.
Need specific QC or validation results — titer, purity, endotoxin, or assay data — for your application? Our scientific team can share what is available for this product and lot on request.
Request validation dataManufacturing
How it's made & quality control
Supplier quality control
Each antibody is validated in the applications it is sold for (WB, IHC, IF/ICC, live-cell imaging) with target-specific staining data on the datasheet.
Peptide toxins and small molecules ship with lot-specific purity data; recombinant and native toxins include activity confirmation.
Lot-specific Certificate of Analysis and product datasheet provided; MSDS available for toxins and chemical reagents.
Supplier-level quality statement. For lot-specific results, request the Certificate of Analysis for your batch.
Answered by our team
Questions from researchers
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Research using this product
Every paper below mentions this product's catalogue number (or product name) in its full text — a text match, not a verified citation. Each entry shows what was measured, the sample type where the paper states it, and the sentence the catalogue number appears in, and a link to the figure showing that data — so you can confirm the use case before citing.
Auto-discovered from Europe PMC by manufacturer number / product name / keyword plus supplier. A match may reference a related product; confirm relevance before citing.
Customization
Customization & add-ons
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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