| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C8H13ClN2OS |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
TG-2-IN-1 is an inhibitor of transglutaminase-2 (TGM-2) that can be used for research on myopia[1]. It is supplied as an off-white to light brown solid (C8H13ClN2OS, MW 220.72) at 98.0% purity.
Physical & Chemical Properties
| CAS Number | 135273-74-4 |
|---|---|
| Molecular Formula | C8H13ClN2OS |
| Molecular Weight | 220.72 g/mol |
| Purity | 98.0% |
| Appearance | Solid |
| Color | Off-white to light brown |
| SMILES | CC(CSC1=[N+](C)C=CN1C)=O.[Cl-] |
| Signaling Pathway | Metabolic Enzyme/Protease |
| Solubility | In Vitro: H2O: 100 mg/mL (453.06 mM; Requires sonication) DMSO: 25 mg/mL (113.27 mM; Requires sonication and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | 4°C, sealed storage, away from moisture. The compound is unstable in solutions, freshly prepared is recommended. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[1]. Roger W. Beuerman, et al. Transglutaminase-2 inhibitors and uses thereof. US20140050779A1.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| H2O | 100 mg/mL (453.06 mM) | requires sonication |
| DMSO | 25 mg/mL (113.27 mM) | requires sonication and warming and heat to 60°C; use freshly opened DMSO (absorbed moisture lowers solubility) |
If water is used as the stock solvent, dilute to the working solution and sterilize it through a 0.22 μm filter before use.
The manufacturer notes that the compound is unstable in solution; prepare solutions fresh before use.
Data provided by the manufacturer.
In Vitro
In human scleral fibroblasts, TG-2-IN-1 (0.1-100 μM, 5 days) inhibits growth and reduces cell number[1].
Cell Proliferation Assay[1]
| Cell Line | scleral fibroblast |
|---|---|
| Concentration | 0.1, 1, 10, 100 μM |
| Incubation Time | 5 days |
| Result | The growth and cell quantity of cells were significantly reduced at 0.1 μM and further decreased in a concentration-dependent manner. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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Tgm2-Catalyzed Covalent Cross-Linking of IκBα Drives NF-κB Nuclear Translocation to Promote SASP in Senescent Microglia. Aging Cell 2025 May;24(5):e14463. PMID: 39749582
TMEM176A drives anti-apoptotic signaling through TGM2-mediated ERK activation in gastric cancer. Int Immunopharmacol 2025 Nov 8;168(Pt 1):115798. PMID: 41207103
