| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | TG 003, (1Z)-1-(3-Ethyl-5-methoxy-2(3H)-benzothiazolylidene)-2-propanone |
| Cas No. | |
| Form | Yellow solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble to 100 mM in DMSO and to 75 mM in ethanol |
| Source | Synthetic |
| Storage |
TG003 is a potent inhibitor of CDC-like kinases (Clk), which regulate alternative splicing through phosphorylation of serine/arginine-rich proteins. In neuroscience, TG003 is valuable for studying RNA splicing mechanisms implicated in neurodegenerative diseases such as ALS and frontotemporal dementia. By modulating splicing factor activity, TG003 offers insights into the regulation of neuronal gene expression and the development of therapeutic strategies targeting splicing dysregulation in neurodegeneration.
Classification: Not a hazardous substance or mixture.
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
TG003 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-515)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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