| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | (±)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione, N-(2,6-dioxo-3-piperidinyl)phthalimide |
| Cas No. | |
| Form | White Solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in 5 mg/ml DMSO |
| Source | Synthetic |
| Storage |
Thalidomide binds to the E3 ubiquitin ligase complex involving CRBN, DDB1, and Cul4A, inhibiting ligase activity. It suppresses TNF synthesis and angiogenesis. In neuroscience, Thalidomide is explored for its immunomodulatory effects and potential to modulate neuroinflammation and neurovascular integrity, although caution is warranted due to its teratogenic properties.
Classification: Very toxic material causing immediate and serious toxic effects. Highly toxic teratogen.
Safety Phrases:
- S22 - Do not breathe dust
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- S24/25- Avoid contact with skin and eyes
Hazard Statements:
- H302 – Harmful if swallowed
- H360 – May damage fertility or the unborn child
Precautionary Statements:
- P201 – Obtain special instructions before use.
- P308 + P313 – If exposed or concerned: Get medical advice/ attention.
Thalidomide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-336)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. Weglicki W.B., et al. (1993) Mol. Cell. Biochem. 129:195.
3. D'Amato R.J., et al. (1994) Proc. Natl. Acad. Sci. USA. 91:4082.
