| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | (3S,3aR,4S,6S,6AR,7S,8S,9bS)-6- (Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl octanoate |
| Cas No. | |
| Form | Colorless wax or white solid. |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in DMSO (65mg/mL); or Ethanol (20mg/mL) |
| Source | Synthetic |
| Storage |
Thapsigargin is a potent inhibitor of the sarco/endoplasmic reticulum Ca²⁺-ATPase (SERCA), leading to depletion of ER calcium stores and induction of ER stress. In neuroscience, Thapsigargin is used to model ER stress-related neuronal dysfunction, a key feature in neurodegenerative diseases such as Alzheimer’s and Parkinson’s. ER stress triggers the unfolded protein response (UPR), which can lead to apoptosis if unresolved. Thapsigargin is instrumental in studying the molecular pathways of calcium homeostasis, protein misfolding, and cell death in neurons.
Classification: D1A- Very Toxic Material Causing Immediate and Serious Toxic Effects, Highly Toxic, D2A- Very Toxic Material Causing Other Toxic Effects, Respiratory sensitiser, D2B- Toxic Material Causing Other Toxic Effects, Moderate skin irritant, Moderate eye irritant
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
- H315- Causes skin irritation.
- H319- Causes serious eye irritation.
- H334- May cause allergy or asthma symptoms or breathing difficulties if inhaled.
- H335- May cause respiratory irritation.
Precautionary statements:
- P261- Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
- P305 + P351 + P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P342 + P311- If experiencing respiratory symptoms: Call a POISON CENTER or doctor/ physician.
Thapsigargin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-399)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. Ganley I.G., et al. (2011) Autophagy. 7(11): 1397-9.
3. Cheng Y., et al. (2013) Autophagy. 9(2): 208-19.
