| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized Powder |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | DMSO, ethanol, acetone or methanol. Centrifuge all product preparations before use (10000 x g 5 min). |
| Source | Natural |
| Storage | |
| Target |
Product details
- Chemical name: (3S,3aR,4S,6S,6aR,7S,8S,9bS)-3,3a-dihydroxy-3,6,9-trimethyl-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-4,6,7,8-tetrayl 6-acetate 4-butanoate 8-[(2Z)-2-methylbut-2-enoate] 7-octanoate.
- CAS number: 67526-95-8
- Molecular formula: C34H48O11.
- Purity: >99%
- Concentration: 100 nM.
- Form: Lyophilized Powder
- Solubility: DMSO, ethanol, acetone or methanol. Centrifuge all product preparations before use (10000 x g 5 min).
- Reconstitution: DMSO, ethanol, acetone or methanol. Centrifuge all product preparations before use (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: SERCA
- Source: Natural
- Activity: Thapsigargin is an extremely tight-binding inhibitor of intracellular Ca2+ pumps, but initially described as a tumor promoting agent which induces rapid Ca2+ release from intracellular stores1. Thapsigargin epoxide is a non-active analogue of Thapsigargin.
Scientific background
Thapsigargin, derived from the plant genus Thapsia1,2, is an extremely tight-binding inhibitor of intracellular Ca2+ pumps. It was initially described as a tumor promoting agent that induces rapid Ca2+ release from intracellular stores3 by the inhibition of the sarcoplasmic endoplasmic reticulm Ca2+-dependent ATPase pump without inositol phosphate formation4. Thapsigargin-induced depletion of Ca2+ stores causes apoptosis in most cell lines5. It has also been shown to cause histamine secretion from rat mast cells6 and to stimulate arachidonic acid metabolism in macrophages7. Its tumour-promoting function probably results, at least partly, from cytotoxicity, causing a wound response in the skin8.Thapsigargin Epoxide is a non-active analogue of Thapsigargin and can be used as a negative control for Thapsigargin activity9,10.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
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