| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | N-(4,5-Dihydro-4-methyl-5-oxo-1,2-d¬ithiolo[4,3-b]pyrrol-6-yl)acetamide |
| Cas No. | |
| Form | Yellow powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | May be dissolved in DMSO (15 mg/ml) |
| Source | Synthetic |
| Storage |
Thiolutin is a sulfur-containing antibiotic that inhibits RNA polymerases and has been shown to block transcription initiation. In neuroscience, it is used to study transcriptional regulation and stress responses in neurons. Thiolutin also exhibits antioxidant properties and can modulate proteasome activity, making it relevant in models of oxidative stress and protein aggregation. These features are particularly important in neurodegenerative diseases where transcriptional dysregulation and oxidative damage contribute to neuronal loss.
Classification: Danger.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
- H300 – Fatal if swallowed
- H330 – Fatal if inhaled
Precautionary Phrases:
- P260 – Do not breathe dust/fume/gas/mist/vapours/spray
- P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician
- P405 – Store locked up
Thiolutin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-375)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. Jia Y., et al. (2010) Cell Stress Chaperones 15: 165.
3. Minamiguchi K., et al. (2001) International J. Cancer. 93: 307.
