| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Source | Microbial — Streptomyces flaveolus strain Tu 1240 |
| Molecular weight | |
| Molecular formula | C22H27NO7 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Tirandamycin A is an antibiotic compound that acts as an inhibitor of bacterial RNA polymerase. It has been reported to possess both antiamoebic and antibacterial properties[1][2]. It has the molecular formula C22H27NO7 and a molecular weight of 417.45 g/mol.
Physical & Chemical Properties
| CAS Number | 34429-70-4 |
|---|---|
| Molecular Formula | C22H27NO7 |
| Molecular Weight | 417.45 g/mol |
| Structure Classification | Antibiotics Disease Research Antibacterial Antibiotics Disease Research Anti-parasitic Antibiotics Other Antibiotics |
| SMILES | O=C(/C1=C(O)\C=C\C(C)=C\[C@H]([C@@H]2[C@@H](C)[C@@]3([H])C([C@]4([H])O[C@]4(C)[C@@](O3)(C)O2)=O)C)NCC1=O |
| Target | RNA Polymerase, Amebae |
| Signaling Pathway | Anti-infection; Cell Cycle/DNA Damage |
| Initial Source | Microbial — Streptomyces flaveolus strain Tu 1240 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Treatment with Tirandamycin A at 60 μM produces slightly stronger inhibition: growth of Entamoeba histolytica HM-1:IMSS falls by 84.2%, and growth of Entamoeba histolytica Col falls by 64.8%. Bacterial RNA polymerase chain initiation and elongation are inhibited by Tirandamycin A, which does not act on mammalian polymerases[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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