| Field | Specification |
|---|---|
| Alternative names | 3,3',5-Triiodothyroacetic acid |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C14H9I3O4 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Tiratricol, also known as 3,3',5-Triiodothyroacetic acid, is an orally available thyroid hormone analog that inhibits pituitary thyroid-stimulating hormone secretion. It acts as an intracellular toxin neutralizer, inhibiting LPS and lipid A cytotoxicity with IC50 values of 20 μM and 32 μM, respectively, and it reduces TNF production in lipopolysaccharide-stimulated macrophages. It also has antiviral activity as an inhibitor of yellow fever virus (Flavivirus), and can bind the RdRp domain of the viral NS5 protein to hinder YFV replication[2]. It is supplied as a white to off-white solid (C14H9I3O4, MW 621.93) at 98.88% purity.
Physical & Chemical Properties
| CAS Number | 51-24-1 |
|---|---|
| Molecular Formula | C14H9I3O4 |
| Molecular Weight | 621.93 g/mol |
| Purity | 98.88% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | O=C(O)CC1=CC(I)=C(OC2=CC=C(O)C(I)=C2)C(I)=C1 |
| Signaling Pathway | Anti-infection; Vitamin D Related/Nuclear Receptor; Apoptosis |
| Solubility | In Vitro: DMSO: ≥ 42 mg/mL (67.53 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) * "≥" means soluble, but saturation unknown. |
| Storage | Powder: -20°C, 3 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | ≥ 42 mg/mL (67.53 mM) | use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); avoid repeated freeze-thaw cycles.
In Vivo
Choose the formulation that suits the animal model and route of administration; percentages are volume ratios of the final working solution. Start from a clear DMSO stock (see In Vitro above), add the co-solvents one at a time in the order listed, mixing after each addition, and prepare the working solution fresh on the day of dosing. If precipitation or phase separation occurs, gentle warming or sonication can help.
Protocol 1
| Composition | 10% DMSO + 40% PEG300 + 5% Tween-80 + 45% saline |
|---|---|
| Result | ≥ 2.5 mg/mL (4.02 mM); clear solution |
| How to prepare | Gives a clear solution at ≥ 2.5 mg/mL (saturation not determined). For 1 mL of working solution: add 100 μL DMSO stock (25.0 mg/mL) to 400 μL PEG300; then 50 μL Tween-80; then 450 μL saline to bring the volume to 1 mL. Saline: dissolve 0.9 g sodium chloride in ddH2O and make up to 100 mL. |
Protocol 2
| Composition | 10% DMSO + 90% (20% SBE-β-CD in saline) |
|---|---|
| Result | ≥ 2.5 mg/mL (4.02 mM); clear solution |
| How to prepare | Gives a clear solution at ≥ 2.5 mg/mL (saturation not determined). For 1 mL of working solution: add 100 μL DMSO stock (25.0 mg/mL) to 900 μL 20% SBE-β-CD in saline. 20% SBE-β-CD in saline: dissolve 2 g SBE-β-CD powder in 10 mL saline until clear (4°C, store up to one week). |
Protocol 3
| Composition | 10% DMSO + 90% Corn Oil |
|---|---|
| Result | ≥ 2.5 mg/mL (4.02 mM); clear solution |
| How to prepare | Gives a clear solution at ≥ 2.5 mg/mL (saturation not determined). Use with caution if continuous dosing will exceed two weeks. For 1 mL of working solution: add 100 μL DMSO stock (25.0 mg/mL) to 900 μL corn oil. |
Data provided by the manufacturer.
In Vitro
Tiratricol (10, 40 μM; 24 h) inhibits YFV infection of Huh-7 cells in a dose-dependent manner and also lowers expression of the viral non-structural protein (NS3)[2].
Western Blot Analysis[2]
| Cell Line | Huh-7 cells |
|---|---|
| Concentration | 0.625, 2.5, 10, and 40 μM |
| Incubation Time | 24 h |
| Result | Remarkably suppressed the viral proteins of NS1, NS2B, NS3, prM and capsid. |
In Vivo
Pretreatment with Tiratricol (0.2 mg/kg/day; po; 6 days) can prevent YFV infection in mice and improve mouse health[2].
| Animal Model | C57BL/6 mice infected with YFV[2] |
|---|---|
| Dosage | 0.2 mg/kg/day |
| Administration | po; day 0–6 post infection (dpi) or from 2 days before infection to 6 dpi |
| Result | Significantly reduce virus titers and protein expression. Restored body weight and improved the survival rate of YFV-infected mice by 40%. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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IodoFinder: Machine Learning-Guided Recognition of Iodinated Chemicals in Nontargeted LC-MS/MS Analysis. Environ Sci Technol 2025 Mar 11;59(9):4530-4539. PMID: 40015982
Van Andel Research Institute. 2026.
