| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C20H25F3N6O2 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
TLR7/8 agonist 4 TFA is a potent agonist of TLR7 and TLR8 that has been reported to have anti-cancer activity[1]. The compound has the molecular formula C20H25F3N6O2 and a molecular weight of 438.45 g/mol.
Physical & Chemical Properties
| CAS Number | 2388520-34-9 |
|---|---|
| Molecular Formula | C20H25F3N6O2 |
| Molecular Weight | 438.45 g/mol |
| SMILES | O=C(O)C(F)(F)F.NC1=NC2=CC=C(N3CCNCC3)C=C2C4=C1NC(CCCC)=N4 |
| Target | TLR7, TLR8 |
| Signaling Pathway | Immunology/Inflammation |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[1]. Shelley Erin ACKERMAN, et al. Macromolecule-supported tlr agonists. WO2020190762A1.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Mutations that help tumors evade immune surveillance invariably accompany tumor growth. Even so, tumorigenesis causes mutated antigens, specifically neoantigens, to accumulate, and after ex vivo stimulation the host immune system readily recognizes them. Delivering these neoantigens to activated dendritic cells through antibody-tumor immune complexes therefore offers a way to overcome the state of "immune ignorance" of the immune system toward the tumor. Indeed, intratumoral injection that delivers tumor-binding antibodies together with dendritic cell adjuvants has successfully induced potent anti-tumor immune responses. Dendritic cell adjuvants, such as Toll-like receptor agonists, thus represent a key potential strategy against cancer[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).
