TNF-R1 Antibody

Tumor necrosis factor receptor 1 (TNF-R1), also known as CD120a or p55/p60, is a high-affinity receptor for tumor necrosis factor-alpha (TNF-α) and a key member of the TNF/TNFR superfamily. Structurally, TNF-R1 features an extracellular domain with multiple cysteine-rich repeats and a cytoplasmic death domain that initiates downstream signaling cascades.

TNF-R1 is widely expressed in the central nervous system, including neurons, astrocytes, and microglia. Upon binding TNF-α, TNF-R1 activates multiple intracellular pathways, including NF-κB-mediated inflammation and caspase-dependent apoptosis. This dual functionality allows TNF-R1 to regulate both cell survival and programmed cell death, depending on the cellular context and signaling environment.

In neurodegenerative disease research, TNF-R1 has emerged as a critical mediator of chronic neuroinflammation and neuronal loss. Aberrant TNF-R1 signaling is implicated in the pathogenesis of Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and amyotrophic lateral sclerosis (ALS). Sustained activation of TNF-R1 can exacerbate oxidative stress, synaptic dysfunction, and glial reactivity—hallmarks of progressive neurodegeneration.

Given its central role in immune signaling and apoptosis, TNF-R1 is a promising therapeutic target for modulating neuroinflammatory responses and protecting neuronal integrity in neurodegenerative disorders.

1 µg/ml of SPC-170 was sufficient for detection of TNFR1 in 20 µg of Hela lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

Cite this product varies by variant:

• SPC-170D — Size: 100 ug: TNF-R1 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-170D, RRID: AB_2703803)
• SPC-170D-A390 — Size: 100 ug: TNF-R1 Antibody: ATTO 390 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-170D-A390, RRID: AB_2703804)
• SPC-170D-A488 — Size: 100 ug: TNF-R1 Antibody: ATTO 488 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-170D-A488, RRID: AB_2703805)
• SPC-170D-A594 — Size: 100 ug: TNF-R1 Antibody: ATTO 594 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-170D-A594, RRID: AB_2703807)
• SPC-170D-APC — Size: 100 ug: TNF-R1 Antibody: APC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-170D-APC, RRID: AB_2703813)
• SPC-170D-BI — Size: 100 ug: TNF-R1 Antibody: Biotin (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-170D-BI, RRID: AB_2703814)
• SPC-170D-FITC — Size: 100 ug: TNF-R1 Antibody: FITC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-170D-FITC, RRID: AB_2703815)
• SPC-170D-HRP — Size: 100 ug: TNF-R1 Antibody: HRP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-170D-HRP, RRID: AB_2703816)
• SPC-170D-PCP — Size: 100 ug: TNF-R1 Antibody: PerCP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-170D-PCP, RRID: AB_2703818)
• SPC-170D-RPE — Size: 100 ug: TNF-R1 Antibody: RPE (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-170D-RPE, RRID: AB_2703819)
• SPC-170S — Size: 12 ug: TNF-R1 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-170S, RRID: AB_2703803)

Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.