| Field | Specification |
|---|---|
| Alternative names | TOF hydrochloride |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C17H22ClNO |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Tofenacin hydrochloride, also known as TOF hydrochloride, is an orally active, weak anticholinergic compound that can be used to study extrapyramidal symptoms and depressive side effects associated with fluphenazine decanoate use[1][2][3][4]. It has the molecular formula C17H22ClNO and a molecular weight of 291.82 g/mol.
Physical & Chemical Properties
| CAS Number | 10488-36-5 |
|---|---|
| Molecular Formula | C17H22ClNO |
| Molecular Weight | 291.82 g/mol |
| SMILES | CNCCOC(C1=C(C)C=CC=C1)C2=CC=CC=C2.Cl |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vivo
In male TNO-Wu rats, Tofenacin (10-25 mg/kg; i.v., i.p.; single dose) hydrochloride (TOF hydrochloride) is excreted extensively in bile; in bile fistula rats, 48.4% of an i.v. 10 mg/kg dose appears in bile over 5 hr, and this excretion depends on rapid biotransformation to conjugated metabolites[3]. In male Sheffield strain rats, Tofenacin (5-25 mg/kg; i.p.; single dose) hydrochloride has no effect on the duration of thiopentone anaesthesia[4]. Likewise, Tofenacin (10-20 mg/kg/day; i.p.; daily; 5-15 days) hydrochloride does not affect the duration of thiopentone anaesthesia in male Sheffield strain rats[4].
| Animal Model | TNO-Wu (male, 150-250 g)[3] |
|---|---|
| Dosage | 10 mg/kg (labelled, i.v. study); 25 mg/kg (non-radioactive, pretreatment) |
| Administration | i.v.; single dose; i.p.; single dose, 30 min before labelled dose |
| Result | Excreted 48.4% of administered radioactivity in bile over 5 hr after i.v. dosing in bile fistula rats. Eliminated 42.2% of administered radioactivity via bile after i.v. dosing in normal rats, exceeding urinary elimination. Reached maximum blood radioactivity concentration immediately, maximum liver radioactivity concentration at 10 min, and maximum bile radioactivity concentration at 15-20 min after i.v. dosing. Exceeded liver radioactivity concentration in bile by 5 min post-dosing, with a maximum bile-to-liver concentration ratio of 7.21 at 20 min. Showed a sharp maximum in biliary excretion of radioactivity in the second 15-min period, followed by prolonged, reduced excretion. Had conjugated metabolites dominate biliary radioactivity even in the first 5 min post-dosing, with free tofenacin accounting for only a small fraction. Decreased biliary excretion of radioactivity in the first hour after administration when pretreated with proadifen. Showed no change in biliary excretion of labelled tofenacin when pretreated with non-radioactive tofenacin. |
| Animal Model | Sheffield strain (male, 250-350 g)[4] |
|---|---|
| Dosage | 5 mg/kg; 10 mg/kg; 25 mg/kg |
| Administration | i.p.; single dose |
| Result | Did not alter thiopentone anaesthesia duration at any tested dose. |
| Animal Model | Sheffield strain (male, 250-350 g)[4] |
|---|---|
| Dosage | 10 mg/kg/day; 20 mg/kg/day |
| Administration | i.p.; daily; 5 days; 15 days |
| Result | Did not alter thiopentone anaesthesia duration at any tested dose or administration duration. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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