| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C18H20N6O3S |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
TPT-004 is a selective, orally active inhibitor of tryptophan hydroxylases (TPH), with IC50 values of 77 nM at TPH1 and 16 nM at TPH2. It shows selectivity for TPH1 relative to other members of the AAAH family and demonstrates efficacy in attenuating peripheral serotonin and reducing colorectal tumor growth in mice[1][2]. It is supplied as a white to off-white solid (C18H20N6O3S, MW 400.45) at 99.90% purity.
Physical & Chemical Properties
| CAS Number | 3032648-15-7 |
|---|---|
| Molecular Formula | C18H20N6O3S |
| Molecular Weight | 400.45 g/mol |
| Purity | 99.90% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | CCN1C2=C(C(NC1=O)=O)N(C(CC3=CN4C=C(SC4=N3)C)=N2)CC5COC5 |
| Signaling Pathway | Metabolic Enzyme/Protease |
| Solubility | In Vitro: DMSO: 125 mg/mL (312.15 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | Powder: -20°C, 3 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 125 mg/mL (312.15 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
In serotonergic BON cells, TPT-004 (72 h) lowers intracellular serotonin levels along a dose-response curve with an IC50 of 0.952 μM[1].
TPT-004 inhibits phenylalanine hydroxylase (PAH) and tyrosine hydroxylase (TH), with IC50 values of 403.5 nM and 1.359 μM, respectively[2].
In Vivo
In the mouse colon carcinoma model MC38, TPT-004 (50 mg/kg; oral gavage; twice daily; for 20 days) reduces tumor growth[1].
| Animal Model | Female C57BL/6N mice (aged 8 weeks) were subcutaneously transplanted with MC38 tumor fragments[1]. |
|---|---|
| Dosage | 50 mg/kg |
| Administration | Oral gavage; twice daily; for 20 days |
| Result | Attenuated the tumor-growth, especially in the initial growth phase. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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