| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized powder. |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | Soluble in 1eq. HCl and in DMSO. Centrifuge all product preparations before use (10000 x g, 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: Ethyl-4-(butylamino)-1-ethyl-6-methylpyrazolo[3,4-b]pyridine-5-carboxylate;hydrochloride.
- Also known as: ICI 136753
- CAS number: 41094-88-6
- Molecular formula: C16H25ClN4O2.
- Purity: >99%
- Concentration: 10-100 µM.
- Form: Lyophilized powder.
- Solubility: Soluble in 1eq. HCl and in DMSO. Centrifuge all product preparations before use (10000 x g, 5 min).
- Reconstitution: Soluble in 1eq. HCl and in DMSO. Centrifuge all product preparations before use (10000 x g, 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: GABA(A) receptors
- Source: Synthetic
- Activity: Tracazolate is an allosteric modulator of GABA(A) receptors, that was shown to potentiate (EC50 = 1.1-16.7 µM) or inhibit (IC50 = 1.2-4.0 µM) GABA-evoked currents in a subunit combination dependent manner1.
- Alternative names: ICI 136753
Scientific background
Tracazolate hydrochloride, a pyrazolopyridine, is a non-sedative anxiolytic compound that acts as an allosteric modulator of GABA(A) receptors. Tracazolate was shown to potentiate the GABA(A) receptor with an EC50 value of 1.1 µM and inhibit with an IC50 value of 1.2 µM1.In addition to its anxiolytic activity, tracazolate possesses anticonvulsant activity that was shown in behavioral studies. Tracazolate seems to cause less adverse interactions in combination with barbiturates and alcohol and demonstrates a wider separation between sedative and therapeutic doses than the benzodiazepines1,2.GABA(A) receptors are members of the Cys-loop superfamily of ligand-gated ion channels. They mediate GABA action, a major inhibitory neurotransmitter, through the central nervous system. They also play an important role in inhibiting cell excitation in the central nervous system, and are considered to be a major target of antiseizure drugs3,4.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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