| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | (2E,4E,6R)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide |
| Cas No. | |
| Form | Beige Solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble to 10 mM in ethanol and to 50 mM in DMSO |
| Source | Synthetic |
| Storage |
Trichostatin A (TSA) is a potent and selective inhibitor of class I and II histone deacetylases (HDACs). By preventing histone deacetylation, TSA promotes chromatin relaxation and transcriptional activation. In neuroscience, TSA is used to study epigenetic regulation of gene expression, synaptic plasticity, and memory formation. It has shown promise in models of neurodegenerative diseases by enhancing neuroprotective gene expression and reducing neuroinflammation.
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
- R20/21/22 - Harmful by inhilation, in contact with skin and if swallowed
- R68 - Possible risk of irreversible effects
Hazard Phrases:
H302-H312-H315-H317-H319-H332-H335
Precautionary Phrases:
P261-P280-P305 + P351 + P338
Trichostatin A (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-254)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. Yoshida, et al. (1990) J Biol Chem. 165: 17174.
3. Drummond D.C., et al. (2005) Annu Rev Pharmacol Toxicol. 45: 495-528.
