| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized powder. |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | 50 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: 5,7-dimethoxy-2-(4-methoxyphenyl)chromen-4-one.
- CAS number: 5631-70-9
- Molecular formula: C18H16O5.
- Purity: >96%
- Concentration: 1-200 µM.
- Form: Lyophilized powder.
- Solubility: 50 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).
- Reconstitution: 50 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: KV1.5, KV11.1, CFTR channels
- Source: Synthetic
- Activity: Trimethylapigenin blocks KV1.5 and hERG channels with IC50 ~ 8 and 30 μM respectively. It also activates CFTR channels1.
Scientific background
Trimethylapigenin is a natural flavone and a fully methylated derivate of apigenin, present in citrus, kaempferia parviflora, etc. Trimethylapigenin inhibits cardiac potassium currents. This compound blocks KV1.5 current in HEK 293 cell line (IC50 = 6.4 μM), and the ultra-rapid delayed rectify K+ current (IKur) in human atrial myocytes (IC50 = 8.0 μM) by binding to the open channels. In addition, trimethylapigenin decreased transient outward K+ current (Ito) in human atrial myocytes, inhibited acetylcholine-activated K+ current (IC50 = 6.8 μM) in rat atrial myocytes1.It has been demonstrated that trimethylapigenin is effective in modulating bacterial drug resistance, and in α-glycosidase inhibition, anti-adipogenesis, anti-carcinoma, anti-inflammation, and chemoprevention. In addition, trimethylapigenin has been found to activate CFTR Cl− channels1.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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