| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | A portion of amino acids 654-683 from the human protein was used as the immunogen for this TrkA antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Its presence leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. Isoform 3 is resistant to NGF, constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. [Isoform 3 information courtesy of UniProt].
- Format: Antigen affinity purified
- Predicted species reactivity: Rat, Chicken
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