| Field | Specification |
|---|---|
| Alternative names | 5-{4-[(6-Hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromen-2-yl)methoxy]benzyl}-1,3-thiazolidine-2,4-dione, Rezulin |
| CAS no. | |
| Applications | |
| Source | Synthetic |
| Molecular weight | |
| Molecular formula | C24H27NO5S |
| Purity | |
| Bioactivity | Agonist |
| Activity | |
| Solubility | Soluble to 100 mM in DMSO and to 10 mM in ethanol |
| SMILES | |
| InChIKey | |
| Form | White solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Troglitazone is a thiazolidinedione class drug that acts as a dual agonist of peroxisome proliferator-activated receptors (PPARα and PPARγ). While primarily developed for diabetes, troglitazone has shown potential in neurodegenerative disease research due to its anti-inflammatory and antioxidant properties. It modulates gene expression involved in lipid metabolism, glucose homeostasis, and mitochondrial function. These effects may help protect neurons from oxidative stress and inflammation, key contributors to neurodegeneration.
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
- R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed
- R40 - Limited evidence of a carcinogenic effect
Troglitazone (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-260)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. Aljada A., et al. (2001) J Clin Endocrinol Metab. 86(7): 3250-3256.
