| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | Tromethamine |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
Trometamol (CAS 77-86-1) is a research-grade small molecule supplied by TargetMol.
Alternative names: Tromethamine
Physical Properties
| CAS Number | 77-86-1 |
|---|---|
| Molecular Formula | C4H11NO3 |
| Molecular Weight | 121.14 g/mol |
| SMILES | NC(CO)(CO)CO |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
Trometamol (Tromethamine) is a proton acceptor used to treat acidemia. It inhibits both isoforms of cyclooxygenases (COX1 and COX2), thereby blocking the conversion of arachidonic acid to pro-inflammatory pro-prostaglandins.
Target(s): COX
Signaling pathway(s): Immunology/Inflammation, Neuroscience
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Centrifuge the closed vial at 3000 rpm for 1–2 minutes to consolidate the powder at the bottom. For electrostatically charged powders, briefly warm the vial to room temperature and allow it to equilibrate before opening. Then add the appropriate solvent directly onto the powder and vortex before sonicating. Avoid tapping the vial vigorously, as this can generate fine powder aerosol.
Product quality is assured — all TargetMol compounds undergo structural confirmation by ¹H NMR and purity determination by HPLC before release. If no effect is observed, consider the following: (1) the IC50 in literature may have been determined in a different cell line or assay format; (2) solubility or cell permeability may be limiting at the tested concentration; (3) establish a concentration gradient (e.g., 0.1–30 µM) tailored to your specific experimental system. A positive control compound with a known cellular effect in your assay is recommended.
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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